2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

PDF 53.7 MB

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-133890A
    Tauro-α-muricholic acid sodium 2260905-08-4
    Tauro-α-muricholic acid sodium (T-α-MCA sodium) is a Taurine (HY-B0351)-conjugated primary Bile acid. Tauro-α-muricholic acid sodium is a FXR antagonist with an IC50 of  28 µM. Tauro-α-muricholic acid sodium attenuates other bile acid-activated FXR signaling. Tauro-α-muricholic acid sodium can be used in the research of Alzheimer's disease, glucose metabolism, and lipid metabolism.
    Tauro-α-muricholic acid sodium
  • HY-145779A
    H-Glu(Met-OH)-OH TFA 99.84%
    H-Glu(Met-OH)-OH TFA (γ-Glu-Met TFA) could induce oxidation of hydroxyl radical.
    H-Glu(Met-OH)-OH TFA
  • HY-B0166S6
    L-Ascorbic acid-d2 82977-10-4 99.90%
    L-Ascorbic acid-d2 is the deuterium labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a colla
    L-Ascorbic acid-d2
  • HY-B0351S2
    Taurine-13C2,15N 2483830-42-6 ≥98.0%
    Taurine-13C2,15N is the 13C- and 15N- labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes.
    Taurine-13C2,15N
  • HY-B2219S2
    Stearic acid-13C18 287100-83-8 99.2%
    Stearic acid-13C18is the 13C-labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
    Stearic acid-13C18
  • HY-N0324S2
    Cholic acid-13C 52886-36-9 99.17%
    Cholic acid-13C is the 13C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
    Cholic acid-13C
  • HY-N10574A
    Queuine dihydrochloride 86496-18-6
    Queuine dihydrochloride is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine dihydrochloride promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine dihydrochloride is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine dihydrochloride can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells.
    Queuine dihydrochloride
  • HY-P990178
    Anti-Mouse NKG2D/CD314 Antibody (CX5)
    Anti-Mouse NKG2D/CD314 Antibody (CX5) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse NKG2D/CD314. Anti-Mouse NKG2D/CD314 Antibody (CX5) reduces cytotoxicity of natural killer cells. Anti-Mouse NKG2D/CD314 Antibody (CX5) can be used for the researches of cancer, infection, inflammation, immunology and metabolic disease, such as colitis and diabetes.
    Anti-Mouse NKG2D/CD314 Antibody (CX5)
  • HY-P990209
    Anti-Mouse IL-7Rα/CD127 Antibody (A7R34)
    Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-7Rα/CD127. Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) blocks IL-7 signaling. Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) can be used for the researches of cancer,infection, inflammation, immunology, cardiovascular and metabolic disease, such as abdominal aortic aneurysms, helicobacter felis-induced gastritis and diabetes.
    Anti-Mouse IL-7Rα/CD127 Antibody (A7R34)
  • HY-W010104
    L-Methionine sulfoxide 3226-65-1 ≥98.0%
    L-Methionine sulfoxide is an orally active oxidation product of Methionine (HY-N0326). L-Methionine sulfoxide can be partially converted into Methionine in the body and participate in the synthesis of glutathione in the liver. L-Methionine sulfoxide provides the body with sulfur activity and can participate in the synthesis of proteins and sulfur-containing compounds.
    L-Methionine sulfoxide
  • HY-W010378
    D-Asparagine 2058-58-4 98.0%
    D-Asparagine (H-D-Asn-OH) acts as a competitive inhibitor of L-asparagine hydrolysis, with a Ki value of 0.24 mM. D-Asparagine serves as a nitrogen source for yeast strains. D-Asparagine is a good substrate for external yeast asparaginase but a poor substrate for internal yeast asparaginase.
    D-Asparagine
  • HY-W011651
    Carbutamide 339-43-5 99.43%
    Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity.
    Carbutamide
  • HY-W012790
    Sodium 2-hydroxybutanoate 5094-24-6 ≥98.0%
    Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite. Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia. Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury.
    Sodium 2-hydroxybutanoate
  • HY-W013058
    Decabromodiphenyl ethane 84852-53-9 98.0%
    Decabromodiphenyl ethane (DBDPE; 1,2-Bis(perbromophenyl)ethane) is a brominated flame retardant. Decabromodiphenyl ethane can exhibit neurotoxicity, thyroid toxicity, reproductive developmental toxicity, hepatotoxicity, and oxidative stress in living organisms.
    Decabromodiphenyl ethane
  • HY-W015444
    2-Hydroxyoctanoic acid 617-73-2
    2-Hydroxyoctanoic acid is a medium chain acyl-CoA synthetase inhibitor with a Ki of 500 μM.
    2-Hydroxyoctanoic acid
  • HY-W704574
    Mergetpa 77102-28-4
    Mergetpa is a reversible Arg-carboxypeptidase inhibitor with high affinity. Mergetpa reduces B1R. Mergetpa blocks the overexpression of IL-1β protein and mRNA in glucose-fed rats. Mergetpa significantly increases the expression of IL-1β protein in the renal cortex. Mergetpa is used to block the conversion of kinins and B2 receptor antagonists into metabolites lacking the C-terminal arginine. Mergetpa inhibits the time-dependent enhancement of the response of isolated rabbit aorta to bradykinin. Mergetpa preserves the chemotactic activity of full-length SDF-1α on cells. Mergetpa reverses hyperglycemia, excessive weight gain, elevated levels of oxidative stress markers and overexpression of inflammatory markers in glucose-fed rats.
    Mergetpa
  • HY-W704966
    2-Stearoyl-sn-glycero-3-phosphocholine 4421-58-3
    2-Stearoyl-sn-glycero-3-PC is a lysophospholipid that contains stearic acid (HY-B2219) at the sn-2 position. It has been found in rabbit myocardium.
    2-Stearoyl-sn-glycero-3-phosphocholine
  • HY-B1469
    Isosorbide 652-67-5 98.76%
    Isosorbide (D-Isosorbide), an orally active vasodilating agent that can be used for the research of heart failure and angina (chest pain). Isosorbide is also an oral hyperosmotic diuretic.
    Isosorbide
  • HY-114333
    Octyl-α-ketoglutarate 876150-14-0 99.9%
    Octyl-α-ketoglutarate (1-Octyl 2-oxopentanedioate) is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional tricarboxylic acid (TCA) cycle, stimulating prolyl hydroxylase (PHD) activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD.
    Octyl-α-ketoglutarate
  • HY-120963
    N-Oleoyl Taurine 52514-04-2 ≥99.0%
    Several different arachidonoyl amino acids, including N-arachidonoyl dopamine and N-arachidonoyl serine, have been isolated and characterized from bovine brain.1 During mass spectral lipidomics analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, were discovered.2 This novel class of compounds is present in kidney and activates members of the transient receptor potential (TRP) family of calcium channels.3 N-Oleoyl taurine is an amino-acyl endocannabinoid isolated from rat brain that may activate TRPV1 and TRPV4.
    N-Oleoyl Taurine
Cat. No. Product Name / Synonyms Application Reactivity